Aldosterone measurements are used in the diagnosis and treatment of Primary aldosteronism (a disorder caused by excessive secretion of aldosterone by the adrenal gland), hypertension caused by primary aldosteronism, selective hyperaldosteronism, oedematous states and other conditions of electrolyte balance.
The IDS-iSYS Aldosterone assay is based on chemiluminescence technology. A biotinylated monoclonal anti-aldosterone antibody is incubated with the sample, an aldosterone acridinium conjugate and streptavidin coated magnetic particles. Following a final incubation step, the particles, using a magnet, undergo a wash step and addition of trigger reagents. The light emitted by the acridinium label is inversely proportional to the concentration of aldosterone in the original sample.